Cafe Sci: The Double Life of STING

[Note: I attend Cafe Sci Virtually because of my schedule. If anyone wants to get together and go as a group, please feel free!]

December's Cafe Sci is both on-site and virtual. To attend either way, you must register here.

Cafe Sci is recorded for later viewing on CSC's YouTube channel.

FREE and open to the public, but Cafe Sci gratefully accepts donations. Parking in the CSC lot costs $6.

December's topic:

### The Double Life of STING: How an Innate Immune Guardian Fights Pathogens and Relieves Cellular Stresses

When cells find DNA where it shouldn't be, they turn on a defense system called cGAS-STING. This system not only causes inflammation to fight invaders but also helps cells make more lysosomes. Lysosomes are like the cell's recycling centers, breaking down waste and dangerous microbes. In this talk, Dr Bo Lv explains how this new discovery might help cells survive in aging and neurodegenerative diseases like Alzheimer's, offering new treatment possibilities.

December's speaker:
Dr Bo Lv is a cell biologist working on ciliary signaling and the innate immune cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway. He earned his B.Sc. in biotechnology from Wuhan University of Technology in 2011 and his Ph.D. in 2017 from the Institute of Hydrobiology, Chinese Academy of Sciences where he was studying the assembly of Chlamydomonas flagella/cilia. He then joined Gregory Pazour lab at Program in Molecular Medicine/UMass Chan Medical School in Massachusetts, where he used CRISPR screening to identify E3 ligases that regulate cilia-mediated hedgehog signaling. After that, he joined the Aging Institute in University of Pittsburgh/UPMC to explore the non-canonical functions of the innate immune cGAS-STING pathway.

Register to attend here.